Subacute sclerosing panencephalitis: measles encephalitis of temperate evolution?

An infantile case of subacute sclerosing panencephalitis with an abnormal ganglioside pattern in the brain.

Recent evidence has suggested that subacute sclerosing panencephalitis (SSPE) is due to temperate infection of the brain by a virus, probably measles virus (Symposium, 1968). In the majority of patients with SSPE, chemical analysis of the brain has shown features of inflammation and demyelination (Cumings, 1965), though 2 patients have been described previously whose brains had abnormal pattern...

Isolation and characterization of a defective measles virus from brain biopsies of three patients in Iran with subacute sclerosing panencephalitis

Immune complexes and visceral deposits of measles antigens in subacute sclerosing panencephalitis.

Immunofluorescence has been used to study visceral organs from a case of subacute sclerosing panencephalitis. Immune complexes were shown as granular deposits of IgG, complement, and measles antigens in renal glomeruli. Measles antigens were detected in the spleen, liver, and lymph nodes from many parts of the body.Immune-complex formation may be important in the aetiology of this disease and p...

Subacute Sclerosing Panencephalitis and Other Lethal Encephalitis Caused by Measles Virus Infection: Pathogenesis and New Approaches to Treatment

Measles-induced encephalitis.

Encephalitis is the most frequent neurological complication of measles virus infection. This review examines the pathophysiology of measles infection and the presentations, diagnosis and treatment of the four types of measles-induced encephalitis including primary measles encephalitis, acute post-measles encephalitis, measles inclusion body encephalitis and subacute sclerosing panencephalitis. ...